Active Studies
Current multi-centre studies open for recruitment in the South East.
Nephrotic Syndrome Biobank
This multi-centre UK study is for children with nephrotic syndrome and is aiming to understand what causes the disease.
Pegcetacoplan in C3G & IC-MPGN
This international multi-centre phase 3 study is assessing efficacy and safety of Pegcetacoplan in C3 glomerulopathy or immune-complex membranoproliverative glomerulonephritis (IC-MPGN).
Access to Transplantation
This UK multi-centre study looks at barriers to kidney transplantation in children.
Rare Renal Disease Registry
National registry for rare kidney diseases. Essential for long-term outcome monitoring and future trials.
Previous Studies
Completed trials and published outcomes.
PlasmaLyte Fluid Trial
This trial was testing a specific type of intravenous fluid (PlasmaLyte) used as the main fluid in children immediately after a kidney transplant.
Relapsing Nephrotic Syndrome
A large UK multi-centre study found that giving a daily low dose of prednisolone for 6 days to children with relapsing nephrotic syndrome at the time of an upper respiratory tract infection did not reduce the risk of them developing a relapse.
Blood Pressure in CKD
Investigated whether controlling blood pressure in children with chronic kidney disease to a lower level would help prevent cardiovascular damage. Results suggested a target blood pressure at the 50th percentile is optimal.
Eculizumab in STEC-HUS
A multi-centre UK trial to see if the complement-blocking drug, eculizumab, was effective in diarrhoea-associated or STEC-HUS. Funding was withdrawn part-way through because the numbers of cases of HUS reduced.
Network Publications
Incidence of AKI in secondary care hospitals: A network audit
Pediatric Nephrology, 2026 in planning
Abstract available on publicationSelected Other Publications
Demographics of childhood hypertension in the UK: a report from the Southeast England
Haseler E, Singh C, Newton J, Melhem N, Sinha MD.
J Hum Hypertens. 2023 Jul;37(7):554-559.
Clinical practice guidelines standardisation of immunosuppressive and anti-infective drug regimens in UK paediatric renal transplantation: the harmonisation programme
Dudley J, Christian M, Andrews A, et al.
BMC Nephrol. 2021 Sep 16;22(1):312.